Posters

Digital quantitation of fibrosis, septa parameters and treatment-induced changes in metabolic dysfunction-associated steatohepatitis F3 fibrosis

Comparing fibrosis distribution in lean versus overweight/obese NASH-cirrhosis patients using SHG/TPE microscopy: An observational analysis

Artificial Intelligence to Measure Fibrosis Change on Liver Biopsy in MAESTRO-NASH, a Phase 3 52-Week Serial Liver Biopsy Study in 966 Patients With NASH Treated With Resmetirom or Placebo

Impact of sampling size on variability of fibrosis assessment in liver needle biopsies using second harmonic generation/two photon excitation microscopy and artificial intelligence analysis based fibrosis staging

Combination therapy of TERN-501, a selective agonist of thyroid hormone receptor (THR) beta with TERN-101, a farnesoid X receptor (FXR) agonist improves nonalcoholic steatohepatitis (NASH) in a GAN diet induced and biopsyconfirmed mouse model

European Association for the Study of the Liver (EASL) Liver Congress (2023)

Validation and utility of artificial intelligence-based zonal annotations as an additional assessment tool for the histopathologic review of fibrosis in non alcoholic steatohepatitis patients

European Association for the Study of the Liver (EASL) Liver Congress (2023)

Artificial intelligence assisted qFibrosis as a pathological “biomarker” to evaluate disease severity in patients with hepatocellular carcinoma

European Association for the Study of the Liver (EASL) Liver Congress (2023)

Artificial intelligence to measure fibrosis change on liver biopsy in MAESTRO-NASH a phase 3 52-week serial liver biopsy study in 966 patients with NASH treated with resmetirom or placebo

European Association for the Study of the Liver (EASL) Liver Congress (2023)

A deep exploration of bridging fibrosis evolution and individual septa parameters in NASH using quantitative second harmonic generation imaging reveals fibrosis changes in natural history and treatment-induced not seen with conventional histology

European Association for the Study of the Liver (EASL) Liver Congress (2023)

Quantification of vessel and bile duct parameters using Second Harmonic Generation in patients with NAFLD across fibrosis stages

European Association for the Study of the Liver (EASL) Liver Congress (2023)

Digital pathology using stain-free imaging indices as a tool for fibrosis quantification in patients with congestive hepatopathy

European Association for the Study of the Liver (EASL) Liver Congress (2023)

Artificial Intelligence analysis of liver biopsies in pre-cirrhotic NASH: qFibrosis explained

European Association for the Study of the Liver (EASL) Liver Congress (2023)

Repeatability and reproducibility assessment and its acceptable standard error of means for qFibrosis system in multi site NASH clinical trials

European Association for the Study of the Liver (EASL) Liver Congress (2023)

Digital pathology with artificial intelligence analyses provides deeper insights into lifestyle intervention-induced fibrosis regression in NASH

European Association for the Study of the Liver (EASL) Liver Congress (2023)

Collagen co-localized with macrovesicular steatosis better differentiates fibrosis progression in non-alcoholic fatty liver disease mouse models

European Association for the Study of the Liver (EASL) Liver Congress (2023)

Digital pathology using stain-free imaging indices allows direct prediction of all-cause mortality, hepatic decompensation and hepatocellular carcinoma development in patients with non-alcoholic fatty liver disease

European Association for the Study of the Liver (EASL) Liver Congress (2023)

Hepatic fat and liver volume reductions-impact on non-alcoholic steatohepatitis trials and potential solutions using concomitant fibrosis with ballooning with fibrosis

European Association for the Study of the Liver (EASL) Liver Congress (2023)

Advancement of artificial intelligence in digital pathology: from exploratory end point to primary end point in non-alcoholic steatohepatitis clinical trials

European Association for the Study of the Liver (EASL) Liver Congress (2023)

Understanding early stage fibrosis in NASH non-human primate model using AI digital pathology

Singapore Hepatology Conference (2023)

Histological Correlation with Portal Pressures and Varices in NASH Cirrhosis using Quantitative Digital Pathology

American Association for the Study of Liver Diseases (AASLD) Liver Meeting (2022)

Quantitative Assessment of Septa Formation and Progression in CDHFD Rat Model of NASH Using SHG/TPEF Microscopy

American Association for the Study of Liver Diseases (AASLD) Liver Meeting (2022)

Quantitative Assessment of Septa Formation and Progression in CDHFD Rat Model of NASH Using SHG/TPEF Microscopy

American Association for the Study of Liver Diseases (AASLD) Liver Meeting (2022)

Repeatability and reproducibility of qFibrosis for automated assessment of liver fibrosis

American Association for the Study of Liver Diseases (AASLD) Liver Meeting (2022)

Use of Second-Harmonic Generation Microscopy for Automated Detection of Septa and Nodules in Needle Liver Biopsies of NASH Cirrhosis

European Association for the Study of the Liver (EASL) Liver Congress (2022)

Clinical relevance of an animal model of nonalcoholic steatohepatitis (NASH) and digital pathology with artificial intelligence (DP-AI) analyses of hepatic fibrosis

European Association for the Study of the Liver (EASL) Liver Congress (2022)

Derivation of Machine Learning Histologic Scores Correlating with Portal Pressures and the Development of Varices in NASH Patients with Cirrhosis

European Association for the Study of the Liver (EASL) Liver Congress (2022)

Impact of Artificial Intelligence Assistive Tool on the Histopathologic Review of Fibrosis in Non-Alcoholic Steatohepatitis Patients

European Association for the Study of the Liver (EASL) Liver Congress (2022)

Magnetic Resonance Elastography (MRE) Demonstrate the Strongest Correlation with Digital Pathology and NASH CRN Fibrosis Assessments, compared to Transient Elastography and Other Assessed Non-Invasive Tests (NITs)

Martic, Miljen, et al. EASL (2022)

Second Harmonic Generation Microscopy can Quantify and Subclassify Early Stages of NASH Fibrosis Progression: Data from a screen-failure cohort of a NASH phase 2 study

European Association for the Study of the Liver (EASL) Liver Congress (2022)

Characterisation of the novel Galectin-3 inhibitor GB1107 on CCl4-induced liver fibrosis in mice

European Association for the Study of the Liver (EASL) Liver Congress 2021

Impact of Resmetirom-Mediated Reductions in Liver Volume and Steatosis Compared with Placebo on the Quantification of Fibrosis using Second Harmonic Generation in a Serial Liver Biopsy Study

European Association for the Study of the Liver (EASL) Liver Congress (2022)

Using qFibrosis analysis to predict disease and survival outcome of patients with hepatocellular carcinoma after curative treatment

European Association for the Study of the Liver (EASL) Liver Congress (2022)

Addressing the Heterogeneity of Fibrosis in Liver Biopsy Specimens with qFibrosis – a New Paradigm for an Old Problem

European Association for the Study of the Liver (EASL) Liver Congress (2022)

The Complexity of Ballooned Hepatocyte (BH) Identification: Time to Rethink Trial Endpoints for Nonalcoholic Steatohepatitis?

American Association for the Study of Liver Diseases (AASLD) The Liver Meeting® Digital Experience (TLMdX) (2021)

Development of Machine Learning Histological Scores that Correlated with Portal Pressures and Development of Varices in NASH patients with Cirrhosis

American Association for the Study of Liver Diseases (AASLD) The Liver Meeting® Digital Experience (TLMdX) (2021)

Unique fibrosis progression and regression features in NAFLD, validation of concept in animal and human studies using artificial intelligence analyses (DP-AI)

American Association for the Study of Liver Diseases (AASLD) The Liver Meeting® Digital Experience (TLMdX) (2021)

SHG/TPEF Microscopy Imaging in the Fibrosis and Steatosis Progression of Nonalcoholic Fatty Liver Disease (NAFLD) in Mouse Models

American Association for the Study of Liver Diseases (AASLD) The Liver Meeting® Digital Experience (TLMdX) (2021)

Second Harmonic Generation (SHG)/Two-Photon Excitation Fluorescence (TPEF) Microscopy Imaging and Quantitative Assessment of Septa Fibrosis in Choline Deficient High Fat Diet (CDHFD) Rat Model of Nonalcoholic Steatohepatitis (NASH)

American Association for the Study of Liver Diseases (AASLD) The Liver Meeting® Digital Experience (TLMdX) (2021)

qVessel, a Machine Learning-based Algorithm, Accurately Stages Liver Biopsies with Chronic Liver Disease, based on Automated Vessel Counting

American Association for the Study of Liver Diseases (AASLD) The Liver Meeting® Digital Experience (TLMdX) (2021)

AI Digital Pathology Using qFibrosis Reveals Heterogeneity of Fibrosis Regression in Hepatitis B and Hepatitis C Patients with SVR

European Association for the Study of the Liver (EASL) Liver Congress (2021)

Digital Pathology with Artificial Intelligence Analyses Reveal New Dynamics of Treatment Induced Fibrosis Regression in Nonalcoholic Steatohepatitis

European Association for the Study of the Liver (EASL) Liver Congress 2021

Dynamic Fibrosis Features in HCV Post-treatment Liver Biopsies and Its Interpretation

Liu, Feng, et al. APASL (2021)

Predict Early Recurrence of Hepatocellular Carcinoma Using Multi-dimensional Artificial Intelligence Analysis of Liver Fibrosis

Liu, I-Ting, et al. APASL (2021)

The Significance Of Quantified Extracellular Matrix Features In Patients With Hepatocellular Carcinoma After Curative Liver Resection

Hsiao, Chih-Yang, et al. APASL (2021)

Dynamic Fibrosis Features in Post-treatment Biopsies and its Interpretation

Paris NASH Meeting (2020)

BMS-986263 (Novel Targeted Lipid Nanoparticle Delivering HSP47 siRNA) Safety and Target Engagement in Patients with Advanced Hepatic Fibrosis: Week 36 Results from a Phase 2 Randomized, Double-blind, Placebo-controlled Trial

European Association for the Study of the Liver (EASL) Annual Congress 2020

Concomitant Zonal Quantification of qSteatosis and qFibrosis in a Sub-study from EMMINENCE, a 12-month Phase 2b NASH study of MSDC-0602K

Harrison, Stephen A., et al. NASH-Tag (2020)

Steatosis and Fibrosis Measured as Continuous Variables on Paired, Serial Liver Biopsies in the Resmetirom (MGL-3196) 36-week Phase 2 NASH Study

American Association for the Study of Liver Diseases (AASLD) Liver Meeting (2019)

qFIBS for the Automated Quantitative Evaluation of Histological Evolution in Pediatric Nonalcoholic Steatohepatitis

American Association for the Study of Liver Diseases (AASLD) Liver Meeting (2019)

Quantitative Imaging and Characterization of Collagen Patterns in High Grade Serous Ovarian Carcinoma (HGSOC)

European Society for Medical Oncology (ESMO) Annual Congress (2019)

Comparison of Various Quantitative and Qualitative Collagen Analysis Methods in Early Liver Fibrosis

Keystone Symposia (2019)

The Glucocorticoid Antagonist ST001 Prevents Development of NASH and Improves Aspects of the Metabolic Syndrome in the DIAMOND™ Mouse Model

European Association for the Study of the Liver (EASL) Annual Meeting (2019)

Morphometric Collagen Analysis Discerns Anti-fibrotic Effects of INT-767 and OCA in NASH Mouse Models Using Second Harmonic Generation Imaging

European Association for the Study of the Liver (EASL) Annual Meeting (2019)

Long-Term Obeticholic Acid Treatment is Associated With Improvements in Collagen Morphometry in Patients With Primary Biliary Cholangitis

European Association for the Study of the Liver (EASL) Annual Meeting (2019)

Multi-photon Microscopy for Characterization of Renal Cell Carcinoma Pseudocapsule: Implications for Tumour Enucleation

European Association of Urology (EAU) Annual Congress (2019)

To Improve the Current Quantitative Assay of Liver Fibrosis by Second Harmonic Generation Microscopy

American Association for the Study of Liver Diseases (AASLD) Annual Meeting (2018)

New Automated Evaluation Tool qFIBS – Quantitative Assessment for Fibrosis, Inflammation, Ballooning, and Steatosis in Patients with Non-Alcoholic Steatohepatitis

American Association for the Study of Liver Diseases (AASLD) Annual Meeting (2018)

A Better Quantitative Method to Evaluate Liver Fibrosis of Short Liver Biopsy Samples in Chronic Hepatitis B Patients.

American Association for the Study of Liver Diseases (AASLD) Annual Meeting (2018)

Assessment of Collagen in Human Idiopathic Pulmonary Fibrosis Using Second Harmonics on Genesis®200.

European Respiratory Society Congress (2018)

Effect of a Small Natural Dietary Compound on Lung Pathology in Airway Inflammation

European Respiratory Society Congress (2018)

Quantitative Imaging and Deep Profiling of Collagen Structure in Triple Negative Breast Cancer

US Chinese American Pathologist (USCAP) Association Annual Meeting (2018)

Development and Validation of an Automated Assessment of Liver Fibrosis Using SHG in Patients with NAFLD

European Association for the Study of the Liver Congress (2017)

Automated, fully quantitative analysis by using second harmonic generation microscopy in the fibrosis progression of nonalcoholic fatty liver disease

European Association for the Study of the Liver Congress (2017)

Quantification of Septa in Liver Fibrosis Using Second Harmonic Generation Imaging

Keystone Symposia on Injury, Inflammation and Fibrosis (2017)

Concurrent Semi-Automated Quantification of Liver Fibrosis and Fat Using Label-free Second Harmonic Generation Imaging in Animal Models

Keystone Symposia on Injury, Inflammation and Fibrosis (2017)

Phenotypical Characterization of Intrahepatic Cholangiocarcinomas Stroma: The More Fibrous, the Less Pejorative

American Association for the Study of Liver Diseases Annual Meeting (2016)

Quantitative Assessment for Fibrosis in NAFLD Using Collagen String Features in Specific Regions for Liver

Asian Pacific Association for the Study of the Liver Meeting (2016)

Digital Whole Slide Imaging and Two Photon Microscopy for Liver Fibrosis Scoring and Quantification

United States & Canadian Academy of Pathology Annual Meeting 2015

Stain-free Detection of Bone Marrow Fibrosis Using Two Photon Excitation and Second Harmonic Generation Microscopy

United States & Canadian Academy of Pathology Annual Meeting 2015