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Caloric Restriction Combined with Immobilization as Translational Model for Sarcopenia Expressing Key- Pathways of Human Pathology
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Tropifexor plus cenicriviroc combination versus monotherapy in non-alcoholic steatohepatitis: Results from the Phase 2b TANDEM study
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Tropifexor for nonalcoholic steatohepatitis: an adaptive, randomized, placebo-controlled phase 2a/b trial
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Digital pathology with artificial intelligence analyses provides greater insights into treatment-induced fibrosis regression in NASH
Naoumov, Nikolai V., et al. Journal of Hepatology 77.5 (2022): 1399-1409.
Developing a New qFIBS Model Assessing Histological Features in Pediatric Patients With Non-alcoholic Steatohepatitis
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Artificial Intelligence Improves Pathologist Agreement for Fibrosis Scores in Nonalcoholic Steatohepatitis Patients
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Multi-photon microscopy for the evaluation of interstitial fibrosis in extended criteria donor kidneys: A proof-of-concept study
So, Wei Zheng, et al. Clinical Transplantation 36.8 (2022): e14717.
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Complexity of ballooned hepatocyte feature recognition: Defining a training atlas for artificial intelligence-based imaging in NAFLD
Brunt, Elizabeth M., et al. Journal of hepatology 76.5 (2022): 1030-1041.
Effects of Valproic Acid and Mitomycin C Combination Therapy in a Rabbit Model of Minimally Invasive Glaucoma Surgery
Seet, Li-Fong, et al. Translational Vision Science & Technology 11.1 (2022): 30-30.
Diet and exercise reduce pre-existing NASH and fibrosis and have additional beneficial effects on the vasculature, adipose tissue and skeletal muscle via organ-crosstalk
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Predict Early Recurrence of Resectable Hepatocellular Carcinoma Using Multi-Dimensional Artificial Intelligence Analysis of Liver Fibrosis
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Reliable computational quantification of liver fibrosis is compromised by inherent staining variation
Astbury, Stuart, et al. The Journal of Pathology: Clinical Research 7.5 (2021): 471-481.
Assessment of renal fibrosis and anti-fibrotic agents using a novel diagnostic and stain-free second-harmonic generation platform
Bhuiyan, Sadman, et al. The FASEB Journal 35.5 (2021): e21595.
Second Harmonic Generation (SHG) Microscopy and Hepatic Venous Pressure Gradient-based Validation of a Novel Histological Staging System for Alcoholic Hepatitis
Rastogi, Archana, et al. Virchows Archiv 479 (2021): 493-506.
Wong, Grace Lai‐Hung, et al. Journal of gastroenterology and hepatology 36.3 (2021): 543-550.
Quantification of Extracellular Matrix Features and its Implications in Hepatocellular Carcinoma Patients after Curative Liver Resection
European Association for the Study of the Liver (EASL) Digital Liver Cancer Summit (2021)
Updates in the Quantitative Assesment of Liver Fibrosis for Nonalcoholic Fatty Liver Disease: Histological Perspective
Soon, Gwyneth, and Aileen Wee. Clinical and Molecular Hepatology27.1 (2021): 44.
The Significance of Fibrosis Quantification as a Marker in Assessing Pseudo-Capsule Status and Clear Cell Renal Cell Carcinoma Prognosis
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Assessment of progressive alterations in collagen organization in the postoperative conjunctiva by multiphoton microscopy
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An Improved qFibrosis Algorithm for Precise Screening and Enrollment into Non-Alcoholic Steatohepatitis (NASH) Clinical Trials
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Multiphoton Microscopic Study of the Renal Cell Carcinoma Pseudocapsule: Implications for Tumour Enucleation
Tan, Yi Quan, et al. Urology 144 (2020): 249-254.
Quantitative stain-free imaging and digital profiling of collagen structure reveal diverse survival of triple negative breast cancer patients
Gole, Laurent, et al. Breast Cancer Research 22 (2020): 1-13.
Long-Term Obeticholic Acid Therapy Improves Histological Endpoints in Patients With Primary Biliary Cholangitis
Bowlus, Christopher L., et al. Clinical Gastroenterology and Hepatology 18.5 (2020): 1170-1178.
Improved quantitative assessment of HBV-associated liver fibrosis using second-harmonic generation microscopy with feature selection
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qFIBS: An Automated Technique for Quantitative Evaluation of Fibrosis, Inflammation, Ballooning, and Steatosis in Patients With Nonalcoholic Steatohepatitis
Liu, Feng, et al. Hepatology 71.6 (2020): 1953-1966.
Quantifying and monitoring fibrosis in non-alcoholic fatty liver disease using dual-photon microscopy
Wang, Yan, et al. Gut 69.6 (2020): 1116-1126.
A novel nutritional supplement prevents muscle loss and accelerates muscle mass recovery in caloric-restricted mice
van den Hoek, Anita M., et al. Metabolism 97 (2019): 57-67.
ECM1 Prevents Activation of Transforming Growth Factor β, Hepatic Stellate Cells, and Fibrogenesis in Mice
Fan, Weiguo, et al. Gastroenterology 157.5 (2019): 1352-1367.
SHG/TPEF-based image technology improves liver fibrosis assessment of minimally sized needle biopsies
Wang, Bingqiong, et al. Hepatology International 13 (2019): 501-509.
Paradis, V., and A. Quaglia. Journal of Hepatology 70.5 (2019): 1016-1018.
Quantification of hepatic steatosis in chronic liver disease using novel automated method of second harmonic generation and two- photon excited fluorescence
Goh, George Boon-Bee, et al. Scientific reports 9.1 (2019): 2975.
Protocols for Culturing and Imaging a Human Ex Vivo Osteochondral Model for Cartilage Biomanufacturing Applications
Duchi, Serena, et al. Materials 12.4 (2019): 640.
qBallooning: Automated Image Detection for Ballooning Degeneration in Non-alcoholic Steatohepatitis (NASH)
Leow, Wei-Qiang, et al. Pathology 51 (2019): S89-S90.
Obeticholic Acid Modulates Serum Metabolites and Gene Signatures Characteristic of Human NASH and Attenuates Inflammation and Fibrosis Progression in Ldlr‐/‐.Leiden Mice
Morrison, Martine C., et al. Hepatology Communications 2.12 (2018): 1513-1532.
Liver Fibrosis Quantification by Digital Whole Slide Imaging and Two Photon Microscopy with Second Harmonic Generation
Jedrzkiewicz, J., et al. Int J Pathol Clin Res 4 (2018): 1-8.
Onofrillo, Carmine, et al. Biofabrication 10.4 (2018): 045006.
Second harmonic generation microscopy provides accurate automated staging of liver fibrosis in patients with non-alcoholic fatty liver disease
Chang, Pik Eu, et al. PLoS One 13.6 (2018): e0199166.
Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016-2030
Estes, Chris, et al. Journal of hepatology 69.4 (2018): 896-904.
Advanced septa size quantitation determines the evaluation of histological fibrosis outcome in chronic hepatitis B patients
Wang, Bingqiong, et al. Modern Pathology 31.10 (2018): 1567-1577.
Quantitative Assessment of Liver Fibrosis (qFibrosis) Reveals Precise Outcomes in Ishak “Stable” Patients on Anti-HBV Therapy
Sun, Yameng, et al. Scientific Reports 8.1 (2018): 2989.
INT-767 Improves Histopathological Features in a Diet-induced ob/ob Mouse Model of Biopsy-confirmed Non-alcoholic Steatohepatitis (NASH)
Roth, Jonathan D., et al. World Journal of Gastroenterology 24.2 (2018): 195.
Improved performance of quantitative collagen parameters versus standard histology in longitudinal assessment of nonadvanced liver fibrosis for chronic hepatitis B
Wang, Y., et al. Journal of Viral Hepatitis 25.5 (2018): 598-607.
Second Harmonic Generation Reveals Subtle Fibrosis Differences in Adult and Pediatric Nonalcoholic Fatty Liver Disease
Liu, Feng, et al. American Journal of Clinical Pathology 148.6 (2017): 502-512.
Samuel, Chrishan S., and Timothy D. Hewitson. Frontiers in Pharmacology 8 (2017): 824.
Wang, Yan, et al. Journal of Gastroenterology and Hepatology 32.9 (2017): 1631-1639.
Automated Evaluation of Liver Fibrosis in CCI4, BDL and TAA Rodent Models Using Second Harmonic Generation/Two-Photon Excited Fluorescence Microscopy
Liu, Feng, et al. Laboratory Investigation (2016), 1-9.
New classification of liver biopsy assessment for fibrosis in chronic hepatitis B patients before and after treatment
Sun, Yameng, et al. Hepatology 65.5 (2017): 1438-1450.
Quantitative imaging of fibrotic and morphological changes in liver of non-alcoholic steatohepatitis (NASH) model mice by second harmonic generation (SHG) and auto-fluorescence (AF) imaging using two-photon excitation microscopy (TPEM)
Yamamoto, Shin, et al. Biochemistry and Biophysics Reports 8 (2016): 277-283.
Almpanis, Zannis, et al. Annals of gastroenterology: quarterly publication of the Hellenic Society of Gastroenterology 29.4 (2016): 445.
Automated biphasic morphological assessment of hepatitis B-related liver fibrosis using second harmonic generation microscopy
Wang, Tong-Hong, et al. Scientific reports 5.1 (2015): 12962.
Multiphoton Microscopy: A Potential Intraoperative Tool for the Detection of Carcinoma In Situ in Human Bladder
Jain, Manu, et al. Archives of Pathology and Laboratory Medicine 139.6 (2015): 796-804.
Evaluation of Area-based Collagen Scoring by Nonlinear Microscopy in Chronic Hepatitis C-induced Liver Fibrosis
Sevrain, David, et al. Biomedical optics express 6.4 (2015): 1209-1218.
Liu, Jia Yun, et al. Endoscopic Microscopy X; and Optical Techniques in Pulmonary Medicine II. Vol. 9304. SPIE, 2015.
Wang, Yan, et al. Chinese Medical Journal 128.02 (2015): 252-258.
Differentiation of Col I and Col III Isoforms in Stromal Models of Ovarian Cancer by Analysis of Second Harmonic Generation Polarization and Emission Directionality
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Minimally Invasive Multiphoton and Harmonic Generation Imaging of Extracellular Matrix Structures in Lung Airway and Related Diseases.
Abraham, Thomas, et al. Pulmonary pharmacology & therapeutics 24.5 (2011): 487-496.
Tai, Dean CS, et al. Journal of biomedical optics 14.4 (2009): 044013-044013.
Fibro-C-index: Comprehensive, Morphology-based Quantification of Liver Fibrosis Using Second Harmonic Generation and Two-Photon Microscopy
Tai, Dean CS, et al. Journal of biomedical optics 14.4 (2009): 044013-044013.
Nonlinear Optical Microscopy: Use of Second Harmonic Generation and Two-Photon Microscopy for Automated Quantitative Liver Fibrosis Studies
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