HistoIndex | AI-based Digital Pathology for Nonalcoholic Steatohepatitis (NASH)

Quantitative, Objective and Repeatable Data for Analysis with Second Harmonic Generation & Two-Photon Excitation (SHG/TPE)

Genesis^®200

Genesis^®200 is the world’s first quantitative, fully-automated, stain-free, multi-organ, 2D & 3D multiphoton imaging system, designed to aid in preclinical studies as well as clinical trials for the drug development of Nonalcoholic Steatohepatitis (NASH).

HistoHepa^©

HistoHepa^© is a suite of image analysis tools that are designed to generate objective and highly accurate quantification so as to enhance the assessment and diagnosis of liver diseases.

AI-based Analysis and Quantification of NASH Features for Treatment Efficacy

qFibrosis

100 collagen features in the overall, central vein, portal tract, and perisinusoidal regions are quantified on a continuous scale.

qFIBS

Tailored for NASH assessment, these measurements quantify up to 275 features with qFibrosis, qInflammation, qBallooning, and qSteatosis.

Quantification of Collagen Fibers on a Continuous Scale with qFibrosis

With qFibrosis, morphological changes in the collagen fibers can be distinguished distinctively, according to multiple parameters, to generate a fully quantitative and accurate analysis. This allows the accurate stratification of liver fibrosis and evaluation of treatment efficacy in NASH clinical trials.

Better Stratification of Clinical Stages

Changes of Collagen Proportional Area (CPA) with NASH CRN stages at baseline of study

Changes of qFibrosis Index with NASH CRN stages at baseline of study

Publication Info: "Fully Automated Quantitative Assessment for NASH Using Genesis^®200 Imaging System, Stephen Harrison et. al. NASH-TAG 2018.

Observation of Trends within Clinical Stages

qFibrosis provides more definitive results and reduction in the No Change category.

Data Source: Gilead Sciences

Positioning and Quantification of Fibrosis, Steatosis, Ballooning and Inflammation with qFIBS

NASH Clinical Study

Fibrosis<br/>(collagen fibers highlighted in green segments)

qFibrosis

Characterizes and quantifies collagen fibers unobservable with conventional stains.

qSteatosis

Quantifies fat measurements and monitors steatosis development.

Hepatocyte Ballooning<br/>(pink segments)

qBallooning

Detects and quantifies the area, number and density of ballooned cells.

Lobular Inflammation<br/>(yellow segments)

qInflammation

Distinguishes and quantifies portal as well as lobular inflammation.

Preclinical NASH Animal Model

Image Analysis

HistoHepa^© is a suite of image analysis tools comprising qFibrosis, qSteatosis, qBallooning and qInflammation, which generate objective and highly accurate quantification so as to enhance the assessment and diagnosis of liver diseases.

Paving the Way for Efficient and Effective NASH Clinical Trial Outcomes

AI-based Analysis and Quantification of NASH Features

Positioning and quantification of fibrosis, inflammation, ballooning and steatosis (qFIBS).

Trending of Data Using a Continuous-scale Measurement

Better stratification and observations of trends even within clinical stages in a continuous-scale measurement.

Enrichment of Clinical Trial Outcomes

Accurately detects biopsies of sub-optimal quality to provide a favorable outcome with lesser patient enrollment required.

Services

WE ALSO PROVIDE PARTNERSHIP OPPORTUNITIES AND SERVICES LIKE:

Tissue Imaging Services
Image Analysis Package
Cell & Collagen Quantification
2D / 3D Visualization
Tissue Morphological Analysis
Data Management

Our site uses cookies or similar technologies to recognise your repeated visits and preferences for us to deliver an optimal browsing experience. Please remember to read our privacy statement.

By clicking on "I Accept" or "X" to continue your browsing on this site, you consent to the use of the cookies. To find out how you can disable cookies on your device, please click here.

I Accept