Quantitative, Objective and Repeatable Data for Analysis with Second Harmonic Generation & Two-Photon Excitation (SHG/TPE)
Genesis®200
Genesis®200 is the world’s first quantitative, fully-automated, stain-free, multi-organ, 2D & 3D multiphoton imaging system, designed to aid in preclinical studies as well as clinical trials for the drug development of Nonalcoholic Steatohepatitis (NASH).
AI-based Analysis and Quantification of NASH Features for Treatment Efficacy
qFibrosis
100 collagen features in the overall, central vein, portal tract, and perisinusoidal regions are quantified on a continuous scale.
qFIBS
Tailored for NASH assessment, these measurements quantify up to 275 features with qFibrosis, qInflammation, qBallooning, and qSteatosis.
Quantification of Collagen Fibers on a Continuous Scale with qFibrosis
With qFibrosis, morphological changes in the collagen fibers can be distinguished distinctively, according to multiple parameters, to generate a fully quantitative and accurate analysis. This allows the accurate stratification of liver fibrosis and evaluation of treatment efficacy in NASH clinical trials.
Better Stratification of Clinical Stages
Changes of Collagen Proportional Area (CPA) with NASH CRN stages at baseline of study
Changes of qFibrosis Index with NASH CRN stages at baseline of study
Publication Info: "Fully Automated Quantitative Assessment for NASH Using Genesis®200 Imaging System, Stephen Harrison et. al. NASH-TAG 2018.
Observation of Trends within Clinical Stages
qFibrosis provides more definitive results and reduction in the No Change category.
Data Source: Gilead Sciences
Positioning and Quantification of Fibrosis, Steatosis, Ballooning and Inflammation with qFIBS
NASH Clinical Study
qFibrosis
Characterizes and quantifies collagen fibers unobservable with conventional stains.
qSteatosis
Quantifies fat measurements and monitors steatosis development.
qBallooning
Detects and quantifies the area, number and density of ballooned cells.
qInflammation
Distinguishes and quantifies portal as well as lobular inflammation.
Paving the Way for Efficient and Effective NASH Clinical Trial Outcomes
AI-based Analysis and Quantification of NASH Features
Positioning and quantification of fibrosis, inflammation, ballooning and steatosis (qFIBS).
Trending of Data Using a Continuous-scale Measurement
Better stratification and observations of trends even within clinical stages in a continuous-scale measurement.
Enrichment of Clinical Trial Outcomes
Accurately detects biopsies of sub-optimal quality to provide a favorable outcome with lesser patient enrollment required.
Services
WE ALSO PROVIDE PARTNERSHIP OPPORTUNITIES AND SERVICES LIKE:
Tissue Imaging Services
Image Analysis Package
Cell & Collagen Quantification
2D / 3D Visualization
Tissue Morphological Analysis
Data Management
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