Quantitative, Objective and Repeatable Data for Analysis with Second Harmonic Generation & Two-Photon Excitation (SHG/TPE)


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Genesis®200 is the world’s first quantitative, fully-automated, stain-free, multi-organ, 2D & 3D multiphoton imaging system, designed to aid in preclinical studies as well as clinical trials for the drug development of Nonalcoholic Steatohepatitis (NASH).


Compilation HistoHepa

HistoHepa© is a suite of image analysis tools that are designed to generate objective and highly accurate quantification so as to enhance the assessment and diagnosis of liver diseases.

AI-based Analysis and Quantification of NASH Features for Treatment Efficacy


100 collagen features in the overall, central vein, portal tract, and perisinusoidal regions are quantified on a continuous scale.


Tailored for NASH assessment, these measurements quantify up to 275 features with qFibrosis, qInflammation, qBallooning, and qSteatosis.

Quantification of Collagen Fibers on a Continuous Scale with qFibrosis

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With qFibrosis, morphological changes in the collagen fibers can be distinguished distinctively, according to multiple parameters, to generate a fully quantitative and accurate analysis. This allows the accurate stratification of liver fibrosis and evaluation of treatment efficacy in NASH clinical trials.

Better Stratification of Clinical Stages


Changes of Collagen Proportional Area (CPA) with NASH CRN stages at baseline of study


Changes of qFibrosis Index with NASH CRN stages at baseline of study

Publication Info: "Fully Automated Quantitative Assessment for NASH Using Genesis®200 Imaging System, Stephen Harrison et. al. NASH-TAG 2018.

Observation of Trends within Clinical Stages

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qFibrosis 1

qFibrosis provides more definitive results and reduction in the No Change category.

Data Source: Gilead Sciences

Positioning and Quantification of Fibrosis, Steatosis, Ballooning and Inflammation with qFIBS

NASH Clinical Study

Fibrosis<br/>(collagen fibers highlighted in green segments)qFibrosis

Characterizes and quantifies collagen fibers unobservable with conventional stains.

Steatosis<br/>(purple segments)qSteatosis

Quantifies fat measurements and monitors steatosis development.

Hepatocyte Ballooning<br/>(pink segments)qBallooning

Detects and quantifies the area, number and density of ballooned cells.

Lobular Inflammation<br/>(yellow segments)qInflammation

Distinguishes and quantifies portal as well as lobular inflammation.

Preclinical NASH Animal Model


Image Analysis

HistoHepa© is a suite of image analysis tools comprising qFibrosis, qSteatosis, qBallooning and qInflammation, which generate objective and highly accurate quantification so as to enhance the assessment and diagnosis of liver diseases.

Paving the Way for Efficient and Effective NASH Clinical Trial Outcomes

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AI-based Analysis and Quantification of NASH Features
Positioning and quantification of fibrosis, inflammation, ballooning and steatosis (qFIBS).
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Trending of Data Using a Continuous-scale Measurement
Better stratification and observations of trends even within clinical stages in a continuous-scale measurement.
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Enrichment of Clinical Trial Outcomes
Accurately detects biopsies of sub-optimal quality to provide a favorable outcome with lesser patient enrollment required.



  • Tissue Imaging Services
  • Image Analysis Package
  • Cell & Collagen Quantification
  • 2D / 3D Visualization
  • Tissue Morphological Analysis
  • Data Management

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