Robert Davidson CFO HistoIndex Final med 01 Nov 2021

HistoIndex Announces Appointment of Robert Davidson as Chief...

Date: 01 Nov 2021

HistoIndex announces the appointment of Mr. Robert Davidson as Chief Financial Officer. Robert is a chartered accountant and joins the HistoIndex senior management with more than 20 years of experience in strategic finance, operations management and corporate governance including previous board-level directorship.

Says Robert on his new beginning at HistoIndex, “It is an honour to be appointed as CFO, as I am inspired by the dedication shown by the exceptional team at HistoIndex in making a difference in the drug development and clinical diagnostics space for better patient outcomes. I believe that my experience along with my growing knowledge of the company’s proprietary technology and business model makes me well aligned with the vision of this company. I am eager to work with Gideon and the HistoIndex team in achieving great success.”


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press 3 20 Oct 2021

HistoIndex and Galecto to Collaborate on Galecto's Phase 2a...

Date: 20 Oct 2021

HistoIndex, a global leading artificial intelligence digital pathology (AI-DP) provider, has announced a collaboration with Galecto, Inc., a biotechnology company focused on the development of novel treatments for fibrosis and cancer.

This collaboration expands HistoIndex's portfolio of fibrosis assessment outside of Nonalcoholic Steatohepatitis (NASH) and other liver diseases. The proprietary stain-free imaging technology, incorporated by Second Harmonic Generation (SHG) along with AI-based algorithms, will be utilized to analyze and quantify collagen-associated parameters as part of Galecto's Phase 2a trial for its oral LOXL2 inhibitor GB2064 in myelofibrosis.

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press 3 18 Aug 2021

HistoIndex’s Stain-free AI-based Digital Pathology Incorpo...

Date: 18 Aug 2021

HistoIndex has announced an agreement with clinical-stage biotechnology company Sagimet Biosciences, where its integrated suite of stain-free imaging with AI-based fully quantitative and zonal analysis of fibrosis will play a role in Sagimet’s Nonalcoholic Steatohepatitis (NASH) Phase 2b multi-center, double-blind, randomized placebo-controlled trial (FASCINATE-2) as both secondary and exploratory efficacy endpoints.

The integrated AI stain-free platform, which comprises the Genesis®200 Second Harmonic Generation (SHG) imaging system and image analysis algorithms, will assess approximately 330 paired patient biopsies for secondary efficacy endpoints. 

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press 3 25 Jun 2021

HistoIndex's AI-Based Digital Pathology Indicates Concomitan...

Date: 25 Jun 2021

HistoIndex's Second Harmonic Generation (SHG) stain-free digital pathology platform has shown marked reduction in liver fibrosis (overall, reduction in perisinusoidal fibrosis, as well as regression of fibrous septa) from baseline to end-of-treatment at 48 weeks, in patients with NASH participating in a Phase 2 FLIGHT-FXR study. The data from the analysis further illustrates the significance of the AI-based digital pathology platform in revealing fibrosis regression in patients treated with Tropifexor (TXR) and its relation to steatosis (liver fat) reduction.

The results of this study were presented at EASL's International Liver Congress™ 2021 (ILC 2021) entitled, "Digital Pathology with Artificial Intelligence Analyses Reveal New Dynamics of Treatment-induced Fibrosis Regression in Nonalcoholic Steatohepatitis". 

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HistoIndex Stain free AI Digital Pathology TNBC Credits IMCB sm 25 Jan 2021

HistoIndex Explores the Clinical Utility of Stain-free AI Di...

Date: 25 Jan 2021

HistoIndex's stain-free AI digital pathology platform, incorporating Second Harmonic Generation (SHG), holds promise as a quantitative tool in the assessment of morphological and architectural changes in collagen fibers within the tumor-stromal microenvironment in patients with TNBC.

This will allow clinicians to better interpret the role of collagen remodeling in tumor progression and its prognostic value. On a larger scale, the tool may greatly aid existing and future TNBC studies that are currently exploring new therapies for targeted treatments.

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press 3 15 Dec 2020

HistoIndex and Consortium Partners Awarded S$1.2M for the De...

Date: 15 Dec 2020

HistoIndex has joined INTErPRET-NAFLD, an international liver R&D collaboration aimed at developing an integrated precision AI diagnostics tool for High-Risk Nonalcoholic Fatty Liver Disease (NAFLD)

Led by the University of Edinburgh, the multi-centre collaboration was recently awarded with a S$1.2M (750,000 Euros) innovative research grant, which will support the collaborators' mutual goal of developing and validating a tool that can accurately identify NAFLD patients who are at a higher risk of progressing to NASH, which can lead to adverse outcomes such as the irreversible cirrhosis, liver cancer and premature death.


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press 3 18 Nov 2020

HistoIndex's AI-Based Platform Demonstrates Zonal Quantifica...

Date: 18 Nov 2020

HistoIndex's Second Harmonic Generation (SHG) stain-free digital pathology platform for the automated quantitative assessment of histological features has shown promising analyses that indicate post-treatment improvements in fibrosis. This was stated at an Oral Presentation entitled, "Safety and Efficacy of Tropifexor in Patients with Fibrotic Nonalcoholic Steatohepatitis: 48-week Results from Part C of the Phase 2 FLIGHT-FXR Study", during AASLD's The Liver Meeting Digital Experience™ 2020.

HistoIndex's quantitative analyses revealed novel aspects of improvement of NASH fibrosis beyond the conventional scoring of liver biopsies for Tropifexor-treated patients. In addition, zonal quantification of fibrosis changes showed a fibrosis improvement in the intermediary area of Zone 2 for Tropifexor-treated patients compared with placebo.

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Fibrous Septa Quantitative assessment of liver fibrosis HistoIndex Credits1 25 May 2020

HistoIndex's AI-based Digital Pathology Platform: A Validate...

Date: 25 May 2020

Singapore medtech company HistoIndex's AI-based stain-free digital pathology platform has long been established as a suitable tool for global clinical guidelines that outline the assessment, prevention and treatment of Chronic Hepatitis B (CHB) infections.

In the latest edition of China's Guidelines for the Prevention and Treatment of Chronic Hepatitis B, the digital pathology platform was recommended for use in providing an automated and quantitative analysis of the liver's morphological characteristics in unstained liver biopsies with high repeatability and accuracy.

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HistoIndex qFIBS 2 1k 10 Nov 2019

qFIBS Demonstrates Suitability for Nonalcoholic Steatohepati...

Date: 10 Nov 2019

qFIBS, a novel automated algorithm developed by HistoIndex, has been shown to accurately distinguish different grades and stages of histological NASH features with a continuous measurement approach. This was highlighted in an international, multicenter collaborative study conducted by pathologists and hepatologists from China, Singapore, Europe and United States.

“In clinical trials today, we depend on the ability to measure critical NASH liver biopsy characteristics especially in determining the extent of fibrosis and steatosis at the various regions of the biopsy, which is very important in assessing post-treatment responses. To assist pathologists in their assessments, it is imperative for pharmaceutical and biotech companies to consider working with a fully quantifiable tool such as qFIBS to provide accurate, standardized and consistent data in clinical trials.” - Dr Stephen Harrison, Medical Director of Pinnacle Clinical Research and President of Summit Clinical Research, and co-author of the multicenter study.

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HistoIndex NASH Preclinical 26 Oct 2019

HistoIndex Announces Global Partnerships to Expand AI-Based...

Date: 26 Oct 2019

The Singapore-based company has fostered partnerships with pharmaceutical and biotech companies, Contract Research Organizations (CROs), academia and government-linked research institutes in empowering NASH drug discovery.

"We are very excited to extend our AI-based SHG platform to preclinical studies to help companies with drug discovery programs select promising lead candidates for further optimization and subsequent clinical development. Our SHG image analysis platform has already been used to analyze the efficacy of a series of promising drug candidates for NASH within various animal models commonly-used by the industry, and we believe these preclinical partnerships will help drive the adoption of our platform significantly." - Dr Poon Thong Yuen, Chief Executive Officer of HistoIndex. 

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