Digestive Disease Week 2019: SHG Technology in POISE Substudy to Quantify Liver Fibrosis


Post-hoc analysis of data from a POISE substudy has shown reduction in fibrosis "supporting the overall trend of improvement or no progression in the histologic components of PBC," a rare autoimmune liver disease of intrahepatic bile ducts leading to progressive fibrosis and eventual cirrhosis, according to a researcher here.

"Measuring collagen content is emerging as a reliable method of quantifying liver fibrosis and has shown evidence of being an effective tool in [patients with] PBC," said Paul Pockros, MD, speaking at Digestive Disease Week.

"Second harmonic generation (SHG) microscopy is a new tissue imaging technology that allows the accurate quantification of several collagen parameters on unstained tissue sections,” he said. “So, it is different than the morphometry we used in the past." Click here to read the full article on Healio.

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