Poster Presentations: AASLD Liver Meeting 2017
At the AASLD Liver Meeting this year, the following presentations were conducted by our distinguished partner and collaborator respectively:
The farnesoid X receptor (FXR) and G protein coupled receptor (GPCR) TGR5 have been implicated in the regulation of metabolism, inflammation and fibrosis in non-alcoholic steatohepatitis (NASH). A dual FXR/TGR5 agonist, INT-767, has been developed and is in early clinical development.
Application of Human NASH-based Transcriptome and Metabolome Profiles in Preclinical Models
By Dr Martine Morrison, TNO, Metabolic Health Research, The Netherlands
Dr. Morrison presented on the representation of human-based molecular disease profiles in an established pre-clinical model for NASH research - the Ldlr-/-.Leiden mouse – and the translational value of this model for the study of NASH-associated hepatic fibrosis.