Poster Presentations: AASLD Liver Meeting 2017
At the AASLD Liver Meeting this year, the following presentations were conducted with mentions of our SHG technology:
The farnesoid X receptor (FXR) and G protein coupled receptor (GPCR) TGR5 have been implicated in the regulation of metabolism, inflammation and fibrosis in non-alcoholic steatohepatitis (NASH). A dual FXR/TGR5 agonist, INT-767, has been developed and is in early clinical development.
This presentation is on the representation of human-based molecular disease profiles in an established pre-clinical model for NASH research - the Ldlr-/-.Leiden mouse – and the translational value of this model for the study of NASH-associated hepatic fibrosis.