Publications & Presentations
2023
Arun J. Sanyal, Patricia Lopez, Eric J. Lawitz, Kathryn J. Lucas, Juergen Loeffler, Won Kim, George B.B. Goh, Jee-Fu Huang, Carla Serra, Pietro Andreone, Yi-Cheng Chen, Stanley H.Hsia, Vlad Ratziu, Diego Aizenberg, Hiroshi Tobita, Aasim M. Sheikh, John M. Vierling, Yoon Jun Kim, Hideyuki Hyogo, Dean Tai, Zachary Goodman, Felicity Schaefer, Ian R.I. Carbarns, Sophie Lamle, Miljen Martic, Nikolai V. Naoumov, Clifford A. Brass. Tropifexor for nonalcoholic steatohepatitis: an adaptive, randomized, placebo-controlled phase 2a/b trial. Nat Med 29, 392–400 (2023). https://doi.org/10.1038/s41591-022-02200-8
Mazen Noureddin, Zachary Goodman, Dean Tai, Elaine L. K. Chng, Yayun Ren, Pol Boudes, Harold Shlevin, Guadalupe Garcia-Tsao, Stephen A. Harrison, Naga P. Chalasani. Alimentary Pharmacology & Therapeutics (2023). https://doi.org/10.1111/apt.17363
2022
Jelle C.B.C. de Jong, Martien P.M. Caspers, Nanda Keijzer, Nicole Worms, Joline Attema, Christa de Ruiter, Serene Lek, Arie G. Nieuwenhuizen, Jaap Keijer, Aswin L. Menke, Robert Kleemann, Lars Verschuren, Anita M. van den Hoek. Aging and Disease (2022). http://dx.doi.org/10.14336/AD.2022.1201
Nikolai V. Naoumov, Dominique Brees, Juergen Loeffler, Elaine Chng, Yayun Ren, Patricia Lopez, Dean Tai, Sophie Lamle, Arun J. Sanyal. Journal of Hepatology (2022). VOLUME 77, ISSUE 5, P1399-1409, NOVEMBER 2022. https://doi.org/10.1016/j.jhep.2022.06.018
Mazen Noureddin, Dean Tai, Elaine L. K. Chng, Yayun Ren, Pol Boudes, Harold Shlevin, Stephen A. Harrison, Naga P. Chalasani, Zachary Goodman (AASLD Poster Presentation, 2022)
Dr. Jason Pik Eu Chang1, Yayun Ren, Ying Zhao, Wei Qiang Leow, Elaine L. K. Chng, Dean Tai, Dr. David E. Kleiner and Dr. Arun J. Sanyal (AASLD Poster Presentation, 2022)
Dr. Xiao Teng, Dr. Hiroaki Yashiro, Dr. Rohan Manohar, Qiang Yang, Alvin Leong and Dr. Gideon Ho
(AASLD Poster Presentation, 2022)
Seet, LF., Chu, S.W., Toh, L.Z. et al. Valproic acid modulates collagen architecture in the postoperative conjunctival scar. J Mol Med 100, 947–961 (2022). https://doi.org/10.1007/s00109-021-02171-2
Vlad Ratziu, Sven Francque, Arun Sanyal. J Hepatol. 2022 Jun; 76(6):1263-1278. doi: 10.1016/j.jhep.2022.04.002.
Feng Liu, Lai Wei, Wei Qiang Leow, Shu-Hong Liu, Ya-Yun Ren, Xiao-Xiao Wang, Xiao-He Li, Hui-Ying Rao, Rui Huang, Nan Wu, Aileen Wee and Jing-Min Zhao. Frontiers. Med., Volume 9 – 27 June 2022. https://doi.org/10.3389/fmed.2022.925357
Presenter: Dr. Stephen Harrison. Oral ePosters sessions, poster tours, and posters will be available online on the ILC platform. (EASL ILC Oral Presentation, 2022)
Impact of Artificial Intelligence Assistive Tool on the Histopathologic Review of Fibrosis in Non-Alcoholic Steatohepatitis Patients
Presenter: Dr. Elaine Chng. Oral ePosters sessions, poster tours, and posters will be available online on the ILC platform. (EASL ILC Poster Presentation, 2022)
Using qFibrosis Analysis to Predict Disease and Survival Outcome of Patients with Hepatocellular Carcinoma after Surgical Treatment
Presenter: Dr. Dean Tai. Oral ePosters sessions, poster tours, and posters will be available online on the ILC platform. (EASL ILC Poster Presentation, 2022)
Addressing the Heterogeneity of Fibrosis in Liver Biopsy Specimens with qFibrosis – a New Paradigm for an Old Problem
Presenter: Dr. David E Kleiner. Oral ePosters sessions, poster tours, and posters will be available online on the ILC platform. (EASL ILC Poster Presentation, 2022)
Use of Second-Harmonic Generation Microscopy for Automated Detection of Septa and Nodules in Needle Liver Biopsies of NASH Cirrhosis
Presenter: Dr. Mazen Noureddin. Oral ePosters sessions, poster tours, and posters will be available online on the ILC platform. (EASL ILC Poster Presentation, 2022)
Derivation of Machine Learning Histologic Scores Correlating with Portal Pressures and the Development of Varices in NASH Patients with Cirrhosis
Presenter: Dr. Mazen Noureddin. Oral ePosters sessions, poster tours, and posters will be available online on the ILC platform. (EASL ILC Poster Presentation, 2022)
Magnetic Resonance Elastography (MRE) Demonstrate the Strongest Correlation with Digital Pathology and NASH CRN Fibrosis Assessments, compared to Transient Elastography and Other Assessed Non-Invasive Tests (NITs)
Presenter: Dr. Miljen Martic. Oral ePosters sessions, poster tours, and posters will be available online on the ILC platform. (EASL ILC Poster Presentation, 2022)
Second Harmonic Generation Microscopy can Quantify and Subclassify Early Stages of NASH Fibrosis Progression: Data from a screen-failure cohort of a NASH phase 2 study
Presenter: Prof. Dr. Quentin Anstee. Oral ePosters sessions, poster tours, and posters will be available online on the ILC platform. (EASL ILC Poster Presentation, 2022)
Clinical relevance of an animal model of nonalcoholic steatohepatitis (NASH) and digital pathology with artificial intelligence (DP-AI) analyses of hepatic fibrosis
Presenter: Dr. Xu Deming. Oral ePosters sessions, poster tours, and posters will be available online on the ILC platform. (EASL ILC Poster Presentation, 2022)
Characterisation of the novel Galectin-3 inhibitor GB1107 on CCl4-induced liver fibrosis in mice
Presenter: Dr. Alison MacKinnon. Oral ePosters sessions, poster tours, and posters will be available online on the ILC platform. (EASL ILC Poster Presentation, 2022)
Gwyneth S T Soon, Feng Liu, Wei-Qiang Leow, Aileen Wee, Lai Wei, Arun J Sanyal. Clin Gastroenterol Hepatol. 2022 Jun 10;S1542-3565(22)00555-9. doi: 10.1016/j.cgh.2022.05.027. Online ahead of print.
Wei Zheng So, Rachel Zui Chih Teo, Li Yin Ooi, Benjamin Yen Seow Goh, Jirong Lu, Anantharaman Vathsala, Thomas Paulraj Thamboo, Ho Yee Tiong. Clinical Transplantation. 2022 May 22;e14717. doi: 10.1111/ctr.14717.
Elizabeth M. Brunt∗, Andrew D. Clouston, Zachary Goodman, Cynthia Guy, David E. Kleiner, Carolin Lackner, Dina G. Tiniakos, Aileen Wee, Matthew Yeh, Wei Qiang Leow, Elaine Chng, Yayun Ren, George Goh Boon Bee, Elizabeth E. Powell, Mary Rinella, Arun J. Sanyal, Brent Neuschwander-Tetri, Zobair Younossi, Michael Charlton, Vlad Ratziu, Stephen A. Harrison, Dean Tai∗, Quentin M. Anstee∗. Journal of Hepatology. Published January 24, 2022. VOLUME 76, ISSUE 5, P1030-1041. https://doi.org/10.1016/j.jhep.2022.01.011.
∗ Joint senior and corresponding authors
Li-Fong Seet; Zhu Li Yap; Stephanie W. L. Chu; Li Zhen Toh; Farah Ilyana Ibrahim; Xiao Teng; Tina T. Wong. Translational Vision Science & Technology January 2022, Vol.11, 30. doi:https://doi.org/10.1167/tvst.11.1.30.
Yoko Miura, Maggie Lam, Jane E Bourke, Satoshi Kanazawa. Life Sci Alliance. 2021 Nov 2;5(1):e202101059. doi: 10.26508/lsa.202101059. Print 2022 Jan. Vol. 5 , No. 1.
2021
Digital Pathology with Artificial Intelligence Analyses (DP-AI) Overcomes the Limitations of Current Scoring Systems in Assessing Fibrosis Regression for NASH F3 Patients
Presenter: Prof. Arun Sanyal. Parallel 10: Diagnostics and Biomarkers of NAFLD. (AASLD TLMdX, Oral Presentation, 2021)
Safety and Efficacy of Tropifexor plus Cenicriviroc Combination Therapy in Adult Patients with Fibrotic NASH: 48 Week Results from the Phase 2b TANDEM Study
Presenter: Dr. Quentin Anstee. Parallel 21: NAFLD and NASH: Clinical Trials of Novel Therapeutics.
(AASLD TLMdX, Oral Presentation, 2021)
Dean Tai, Amon Asgharpour, Yayun Ren, Mulugeta Seneshaw, Faridoddin Mirshahi, Arun Sanyal.
(AASLD TLMdX e-Poster, 2021)
Elizabeth M Brunt, Andrew Clouston, Zachary Goodman, Cynthia Guy, David E. Kleiner, Karolin Lackner, Dina G. Tiniakos, Aileen Wee, Matthew Yeh, Wei Qiang Leow, Arun Sanyal, Brent Tetri, Mary Rinella, Vincent Wong, George Goh Boon Bee, Elizabeth Powell, Lai Wei, Zobair Younossi, Michael Charlton, Vlad Ratziu, Stephen Harrison, Elaine Chng, Yayung Ren, *Dean Tai, *Quentin M Anstee. (AASLD TLMdX e-Poster, 2021)
Mazen Noureddin, Zachary D. Goodman, Dean Tai, Yayun Ren, Elaine Chng, Pol Boudes, Harold Shlevin, Stephen Harrison, Naga P. Chalasani. (AASLD TLMdX e-Poster, 2021) (Poster of Distinction).
qFIBS Performance in Pediatric Non-Alcoholic Steatohepatitis
Feng Liu1*, Lai Wei*, Wei Qiang Leow, Shu-Hong Liu, Xiao-Xiao Wang, Xiao-He Li, Hui-Ying Rao, Rui Huang, Nan Wu, Aileen Wee, Jing Min Zhao. (AASLD TLMdX e-Poster, 2021)
Xiao Teng, Rohan Manohar, Hiroaki Yashiro, Qiang Yang, Alvin Leong, Gideon Ho.
(AASLD TLMdX e-Poster, 2021)
Wang Xiaoxiao, Rui Jin, Xiao-He Li, Qiang Yang, Xiao Teng, Nan Wu, Hui-Ying Rao, Feng Liu.
(AASLD TLMdX e-Poster, 2021)
Zhengxin Li, Tingting Zhu, Zhao Zhi-min, Qiang Yang, Xiao Teng, Ya-yun Ren, Dean Tai, Ian Wanless, Cheng-hai Liu. (AASLD TLMdX e-Poster, 2021)
Liu, I.-T.; Yen, C.-S.; Wang, W.-L.; Tsai, H.-W.; Chu, C.-Y.; Chang, M.-Y.; Hou, Y.-F.; Yen, C.-J. Predict Early Recurrence of Resectable Hepatocellular Carcinoma Using Multi-Dimensional Artificial Intelligence Analysis of Liver Fibrosis. Cancers 2021, 13, 5323. https://doi.org/10.3390/cancers13215323
Anita M. van den Hoek, Jelle C.B.C. de Jong, Nicole Worms, Anita van Nieuwkoop, Marijke Voskuilen, Aswin L. Menke, Serene Lek, Martien P.M. Caspers, Lars Verschuren, Robert Kleemann. Metabolism. 2021 Nov;124:154873. doi: 10.1016/j.metabol.2021.154873.
Nikolai V. Naoumov, Dominique Brees, Juergen Loeffler, Elaine Chng, Yayun Ren, Patricia Lopez, Dean Tai, Arun Sanyal, Sophie Lamle. PO#889. Available to registered delegates.
(EASL International Liver Congress Poster Presentation, 2021) Read press release here.
Feng Liu, Yameng Sun, Dean Tai, Yayun Ren, Elaine Chng, Aileen Wee, Pierre Bedossa, Rui Huang, Jian Wang, Lai Wei, Hong You, Huiying Rao. Available to registered delegates.
(EASL International Liver Congress Poster Presentation, 2021)
Digital Pathology to Assess Pathobiology and Treatment Response in NAFLD
Presenter: Dr. Nikolai V. Naoumov. EASL Basic Science Seminar. Artificial intelligence, “Omics” and Big Data in Liver Research – Emerging Technologies. Available to registered delegates.
(EASL International Liver Congress, 2021)
Stuart Astbury, Jane I Grove, David A Dorward, Indra N Guha, Jonathan A Fallowfield, Timothy J Kendall. J Pathol Clin Res. 2021 Jun 2. doi: 10.1002/cjp2.227. Online ahead of print.
Assessment of Renal Fibrosis and Anti‐fibrotic Agents using a Novel Diagnostic and Stain‐free Second‐Harmonic Generation Platform
Sadman Bhuiyan, Matthew Shen, Sharenya Chelvaretnam, Andre Y. Tan, Gideon Ho, Mohammed Akhter Hossain, Robert E. Widdop, Chrishan S. Samuel. FASEB Volume 35, Issue 5, May 2021, e21595. First published 28 April 2021. https://doi.org/10.1096/fj.202002053RRR.
Rastogi, A., Patil, N., Maiwall, R. et al. Second-harmonic generation (SHG) microscopy and hepatic venous pressure gradient-based validation of a novel histological staging system for alcoholic hepatitis. Virchows Arch 479, 493–506 (2021). https://doi.org/10.1007/s00428-021-03089-3
Artificial Intelligence in Prediction of Non-alcoholic Fatty Liver Disease and Fibrosis
Grace Lai-Hung Wong, Pong-Chi Yuen, Andy Jinhua Ma, Anthony Wing-Hung Chan, Howard Ho-Wai Leung and Vincent Wai-Sun Wong. 2021 Mar;36(3):543-550. doi: 10.1111/jgh.15385. PMID: 33709607.
Presenting Author: Prof. Dr. Kai-Wen Huang. (Digital Liver Cancer Summit e-Poster, 2021)
The Significance Of Quantified Extracellular Matrix Features In Patients With Hepatocellular Carcinoma After Curative Liver Resection
Presenting Author: Prof. Dr. Chih-Yang Hsiao. (APASL Poster Presentation, 2021)
Dynamic Fibrosis Features in HCV Post-treatment Liver Biopsies and Its Interpretation
Presenting Author: Prof Feng Liu. (APASL Poster Presentation, 2021)
Predict Early Recurrence of Hepatocellular Carcinoma Using Multi-dimensional Artificial Intelligence Analysis of Liver Fibrosis
Presenting Author: Prof. Dr. I-ting Liu. (APASL Poster Presentation, 2021)
Chih-Yang Hsiao, Xiao Teng, Tung-Hung Su, Po-Huang Lee, Jia-Horng Kao, Kai-Wen Huang. Quantitative Imaging in Medicine and Surgery, North America. Submitted Mar 05, 2020. Accepted for publication Sep 11, 2020. Online Nov 11, 2020. Published in January 2021. Available at https://qims.amegroups.com/article/view/55021. doi: 10.21037/qims-20-394.
Soon G, Wee A. Updates in the quantitative assessment of liver fibrosis for nonalcoholic fatty liver disease: Histological perspective. Clin Mol Hepatol. 2021 Jan;27(1):44-57. doi: 10.3350/cmh.2020.0181. Epub 2020 Nov 19. PMID: 33207115; PMCID: PMC7820194.
2020
Safety and Efficacy of Tropifexor in Patients with Fibrotic Nonalcoholic Steatohepatitis: 48-week Results from Part C of the Phase 2 FLIGHT-FXR Study
Prof. Arun Sanyal. 13-16 November 2020. Available to registered attendees of the TLMx. Read press release here. (The Liver Meeting Digital Experience (TLMx), 2020)
Wei-Qiang Leow, Pierre Bedossa, Feng Liu, Lai Wei, Kiat-Hon Lim, Wei-Keat Wan, Yayun Ren, Jason Pik-Eu Chang, Chee-Kiat Tan, Aileen Wee, George Boon-Bee Goh. Diagnostics. 2020; 10(9):643/ https://doi.org/10.3390/diagnostics10090643
Qin C, Yin H, Liu H, Liu F, Du Y, Xu T. Diagnostics (Basel). 2020;10(11):895. Published 2020 Nov 2. doi:10.3390/diagnostics10110895.
Li-Fong Seet, Stephanie W. L. Chu, Xiao Teng, Li Zhen Toh, and Tina T. Wong. Biomed Opt Express. 2020 Oct 19;11(11):6495-6515. doi: 10.1364/BOE.403555. eCollection 2020 Nov 1.
Innovations: Utilizing Digital Methods and New Technology – HistoIndex
Dean Tai. 27 October 2020. (Liver Forum Histology Series Session 2, 2020)
Dynamic Fibrosis Features in Post-treatment Biopsies and its Interpretation
Elaine Lay Khim Chng, Dean Tai, Yayun Ren, Pierre Bedossa. Digital Paris 22-23 October 2020.
(NASH Meeting Poster Presentation, 2020)
Eric Lawitz et. al. Available to registered attendees of the DILC 2020.
(EASL Digital International Liver Congress, 2020)
Liu F, Boon-Bee Goh G, Tiniakos D, Wee A, Leow W, Zhao JM, Rao HY, Wang X, Wang Q, Wan WK, Lim KH, Romero-Gomez M, Petta S, Bugianesi E, Tan CK, Harrison SA, Anstee QM, Chang PJ, Wei L. Hepatology 2020 Jun;71(6):1953-1966. doi:10.1002/hep.30986. Epub 2020 May 7. HEPATOLOGY Honor Roll: Editor’s Choice
Concomitant Zonal Quantification of qSteatosis and qFibrosis in a Sub-study from EMMINENCE, a 12-month Phase 2b NASH study of MSDC-0602K
Stephen A. Harrison, Dean C.S. Tai, Yayun Ren, Elaine L.K. Chng, Howard C. Dittrich.
(NASH-Tag Poster Presentation, 2020)
Christopher L. Bowlus, Paul J. Pockros, Andreas E. Kremer, Albert Parés, Lisa M. Forman, Joost P.H. Drenth, Stephen D. Ryder, Luigi Terracciano, Yuying Jin, Alexander Liberman, Richard Pencek, Uche Iloeje, Leigh MacConell, Pierre Bedossa. Clin Gastroenterol Hepatol. 2020 May;18(5):1170-1178.e6. doi: 10.1016/j.cgh.2019.09.050.
LYi Quan Tan, Wy Keat Tay, Li Yin Ooi, Thomas Paulraj Thamboo, Ho Yee Tiong. Urology. 2020 Oct;144:249-254. doi: 10.1016/j.urology.2020.06.064.
Prognostic Value of Desmoplastic Stroma in Intrahepatic Cholangiocarcinoma
Nathalie Guedj, Lorraine Blaise, François Cauchy, Miguel Albuquerque, Olivier Soubrane, Valérie Paradis. Mod Pathol. 2020 Aug 28. doi: 10.1038/s41379-020-00656-y. Online ahead of print.
Yan Wang, Grace Lai-Hung Wong, Fang-Ping He, Jian Sun, Anthony Wing-Hung Chan, Jinlian Yang, Sally She-Ting Shu, Xieer Liang, Yee Kit Tse, Xiao-Tang Fan, Jinlin Hou, Henry Lik-Yuen Chan, Vincent Wai-Sun Wong. Gut, 2020 Jun;69(6):1116-1126. http://dx.doi.org/10.1136/gutjnl-2019-318841.
Zhenjie Zhuang, Huanjia Qu, Wenjun Yang, Juan Liu, Fuyan Wang, Yinlan Liu, Jianping Ding, Junping Shi. Ann Hepatol. May-Jun 2020;19(3):313-319. https://doi.org/10.1016/j.aohep.2019.11.003.
Laurent Gole, Joe Yeong, Jeffrey Chun Tatt Lim, Kok Haur Ong, Hao Han, Aye Aye Thike, Yong Cheng Poh, Sidney Yee, Jabed Iqbal, Wanjin Hong, Bernett Lee, Weimiao Yu, Puay Hoon Tan. Breast Cancer Res 22, 42 (2020). https://doi.org/10.1186/s13058-020-01282-x.
C.-Y.Hsiao, X.Teng, T.-H.Su. P.-H.Lee, J.-H.Kao, K.-W.Huang. Clin Res Hepatol Gastroenterol. 2020 Feb;44(1):12-20. doi: 10.1016/j.clinre.2019.04.003.
2019
Stephen A Harrison, Dean Tai, Ya-Yun Ren, Rebecca A. Taub, Mustafa Bashir.
11 November 2019. (AASLD Poster Presentation, 2019)
Feng Liu, Jingmin Zhao, Leow Wei-Qiang, Ya-Yun Ren, Xiaoxiao Wang, Xiaohe Li, Huiying Rao, Wei Zhang, Aileen Wee, Lai Wei. 10 November 2019. (AASLD Poster Presentation, 2019)
Quantitative SHG Microscopy: Unraveling the Nano-architecture of the Cirrhotic Liver
Ian R. Wanless. Clin Res Hepatol Gastroenterol. 2019 Aug 12. pii: S2210-7401(19)30174-3. doi: 10.1016/j.clinre.2019.07.009.
Weiguo Fan, Tianhui Liu, Wen Chen, Seddik Hammad, Thomas Longerich, Ingrid Hausser, Yadong Fu, Nan Li, Yajing He, Cui Liu, Yaguang Zhang, Qiaoshi Lian, Xinhao Zhao, Chenghua Yan, Li Li, Chunyan Yi, Zhiyang Ling, Liyan Ma, Xinyan Zhao, Hufeng Xu, Ping Wang, Min Cong, Hong You, Zhihong Liu, Yan Wang, Jianfeng Chen, Dangsheng Li, Lijian Hui, Steven Dooley, Jinlin Hou, Jidong Jia, and Bing Sun. Gastroenterology. 2019 Nov;157(5):1352-1367.e13. doi: 10.1053/j.gastro.2019.07.036.
Anita M. van den Hoek, Gerben C.M. Zondag, Lars Verschuren, Christa de Ruiter, Joline Attema, Elly C. de Wit, Anne M.K. Schwerk, Bruno Guigas, Serene Lek, Annemarie Rietman, Rein Strijker, Robert Kleemann. https://doi.org/10.1016/j.metabol.2019.05.012. Metabolism – Clinical and Experimental, August 2019, Volume 97, Pages 57–67
Bingqiong Wang, Yameng Sun, Jialing Zhou, Xiaoning Wu, Shuyan Chen, Yiwen Shi, Shanshan Wu, Hui Liu, Yayun Ren, Xiaojuan Ou, Jidong Jia, and Hong You. Hepatol Int 2019 Jul;13(4):501-509. doi: 10.1007/s12072-019-09955-2.
MRI-PDFF Response in MGL-3196 and Placebo Treated Patients Predicts Reduction in Ballooning and Inflammation Components of NAS and NASH Resolution in a 36-week Serial Liver Biopsy Study
Stephen A. Harrison, Mustafa R. Bashir, Cynthia Guy, Rebecca Taub.
(EASL Poster Presentation, 2019)
Rebecca Caffrey. (EASL Poster Presentation, 2019)
Andreas E. Kremer, Christopher L. Bowlus, Pierre Bedossa, Albert Parés, Lisa M. Forman, Joost P.H. Drenth, Stephen Ryder, Luigi Terracciano, Yuying Jin, Alexander Liberman, Richard Pencek, Leigh MacConell, Paul J. Pockros. (EASL Poster Presentation, 2019)
Li Chen, Mathieu Petitjean, Luciano Adorini, Jonathan Roth. (EASL Poster Presentation, 2019)
George Boon-Bee Goh, Wei Qiang Leow, Shen Liang, Wei Keat Wan, Tony Kiat Hon Lim, Chee Kiat Tan & Pik Eu Chang. Scientific Reports (2019) 9:2975, https://doi.org/10.1038/s41598-019-39783-1.
A Quantitative Method (qVessel) Analysis: The Characteristics of Hepatic Vascular Changes in Different Causes
Zheng Xin Li, Zhao Zhi Min, Cheng Hai Liu, Ya Yun Ren, Xiao Teng, Dean Tai.
(APASL Poster Presentation, 2019)
Comparison of Various Quantitative and Qualitative Collagen Analysis Methods in Early Liver Fibrosis
Reinout Stoop, Martine Morrison, Serene Lek, Arianne van Koppen, Lars Verschuren, Nicky van Trigt, Natascha van Lent, Roeland Hanemaaijer.Integrated Pathways of Disease in NASH and NAFLD. (Keystone Symposia, 2019)
Ruby Huang. (ESMO Congress Poster Presentation, 2019)
Quan Tan Yi, Tay Wy Keat, Ooi Yin Li, Teo Zui Chih Rachel, Tiong Ho Yee.
(34th Annual EAU Congress)
Serena Duchi, Stephanie Doyle, Timon Eekel, Cathal D. O’Connell , Cheryl Augustine, Peter Choong, Carmine Onofrillo and Claudia Di Bella. MDPI, Materials 2019, 12(4), 640; https://doi.org/10.3390/ma12040640.
Digital Pathology: What is the Future?
V. Paradis, A. Quaglia. Journal of Hepatology. May 2019, Volume 70, Issue 5, Pages 1016–1018. https://doi.org/10.1016/j.jhep.2018.03.023.
2018
Wei-Qiang Leow, Wei Keat Wan, Josh Jie Hua Loh, Syed Muhammad Fahmy Alkaff, Dean C.S. Tai, Yayun Ren, George Boon-Bee Goh, Chee Kiat Tan, Pik Eu Chang, Kiat Hon Lim. 51. S89-S90. 10.1016/j.pathol.2018.12.236.
Morrison MC, Verschuren L, Salic K, vanden Hoek AM, Menke A, Verheij J, Iruarrizaga-Lejarreta M, Turner S, Schwerk A, van Koppen A, Wielinga P Y, Mato JM, Hanemaaijer R, Alonso C, Kleemann R. (HistoIndex Breakfast Meeting Poster Presentation, 2018)
Collagen Structure Similarities between in vitro and in vivo Liver Fibrosis Models
Stroebel S, Rupp J, Kostadinova R, Gart E, Salic K, Morrison MC, Kleemann R, Lek S, Thoma E, Guye P. (HistoIndex Breakfast Meeting Poster Presentation, 2018)
Bingqiong Wang, Yameng Sun, Jialing Zhou, Xiaoning Wu, Shuyan Chen, Yiwen Shi, Shanshan Wu, Xiaojuan Ou, Jidong Jia and Hong You. (AASLD Poster Presentation, 2018)
To Improve the Current Quantitative Assay of Liver Fibrosis By Second Harmonic Generation Microscopy
Kai-Wen Huang, Hepatitis Research Center, National Taiwan University Hospital.
(AASLD Poster Presentation, 2018)
Feng Liu, Boon Bee George Goh, Dina Tiniakos, Aileen Wee, Leow Wei-Qiang, Jingmin Zhao, Huiying Rao, Xiao-Xiao Wang, Qin Wang, Wei-Keat Wan, Kiat Hon Lim, Manuel Romero-Gomez, Salvatore Petta, Elisabetta Bugianesi, Chee-Kiat Tan, Stephen A. Harrison, Quentin M. Anstee, Jason Chang and Lai Wei. (AASLD Oral Presentation, 2018)
David A Fraser, Xiaoyu Wang, Cristina Alonso, Serene Lek, Tore Skjaeret, Detlef Schuppan.
(AASLD Poster Presentation, 2018)
Jolanta Jedrzkiewicz, Mary P Bronner, Mohamed E Salama, Jessica Kohan, Leslie R Rowe, Dean Tai, Elisabeth Malmberg and Erinn Downs-Kelly. Int J Pathol Clin Res 4:078. doi.org/10.23937/2469-5807/1510078.
Morrison MC, Verschuren L, Salic K, Verheij J, Menke A, Wielinga PY, Iruarrizaga-Lejarreta M, Gole L, Yu W, Turner S, Caspers MPM, Martínez-Arranz I, Pieterman EJ, Stoop R, van Koppen A,van den Hoek AM, Mato JM, Hanemaaijer R, Alonso C, Kleemann R. Hepatology Communications. 2018 Oct 29;2(12):1513-1532. doi: 10.1002/hep4.1270.
Biofabrication of Human Articular Cartilage: A Path Towards the Development of a Clinical Treatment
Carmine Ono, Serena Duchi, Cathal D O’Connell, Romane Blanchard, Andrea J O’Connor, Mark Scott, Gordon G Wallace, Peter FM Choong and Claudia Di Bella. Biofabrication, Volume 10, Number 4, October 2018. https://doi.org/10.1088/1758-5090/aad8d9
Chris Estes, Quentin M. Anstee, Maria Teresa Arias-Loste, …, Lai Wei, Stefan Zeuzem, Homie Razavi. J Hepatol. 2018 Oct;69(4):896-904. doi: 10.1016/j.jhep.2018.05.036. Epub 2018 Jun 8.
Pik Eu Chang, George Boon Bee Goh, Wei Qiang Leow, Liang Shen, Kiat Hon Lim, Chee Kiat Tan. PLoS ONE 13(6):e0199166. https://doi.org/10.1371/journal.pone.0199166.
Y. Wang, X. Liang, J. Yang, H. Wang, D. Tan, S. Chen, J. Cheng, Y. Chen, J. Sun, F. Rong, W. Yang, H. Liu, Z. Liu, Y. Zheng, J. Liang, S. Li, Z. Liu, J. Hou. Journal of Viral Hepatitis, https://doi.org/10.1111/jvh.12835.
Bingqiong Wang, Yameng Sun, Jialing Zhou, Xiaoning Wu, Shuyan Chen, Shanshan Wu, Hui Liu, Tailing Wang, Xiaojuan Ou, Jidong Jia, Hong You. Modern Pathology, https://doi.org/10.1038/s41379-018-0059-x.
Yameng Sun, Jialing Zhou, Xiaoning Wu, Yongpeng Chen, Hongxin Piao, Lungen Lu, Huiguo Ding, Yuemin Nan, Wei Jiang, Tailing Wang, Hui Liu, Xiaojuan Ou, Aileen Wee, Neil D. Theise, Jidong Jia, Hong You. Nature.com, Scientific Reports. 2018 Feb 14;8(1):2989. doi: 10.1038/s41598-018-21179-2.
Roth JD, Feigh M, Veidal SS, Fensholdt LK, Rigbolt KT, Hansen HH, Chen LC, Petitjean M, Friley W, Vrang N, Jelsing J, Young M. INT-767 improves histopathological features in a diet-induced ob/ob mouse model of biopsy-confirmed non-alcoholic steatohepatitis. World J Gastroenterol. 2018 Jan 14;24(2):195-210. doi: 10.3748/wjg.v24.i2.195. PMID: 29375205; PMCID: PMC5768938.
Fully Automated Quantitative Assessment for NASH Using the Genesis®200 Imaging System
Stephen A. Harrison, MD, Zachary Goodman, MD, PhD, Katherine M. Cebe, MD, Lakshmi Alaparthi, Fanny Monge, Peter G. Traber, MD, Dean Tai, PhD. (NASH-TAG Presentation, 2018)
Assessment of Collagen in Human Idiopathic Pulmonary Fibrosis Using Second Harmonics on Genesis®200.
S. Royce, C. Erdem, A. Tan, J. Jaffar, G. Westall, J. Bourke, C. Samuel, R. Widdop.
(European Respiratory Society Congress Poster Presentation, 2018)
Effect of a Small Natural Dietary Compound on Lung Pathology in Airway Inflammation
Amlan Chakraborty, Jennifer C. Boer, Simon G. Royce, Cordelia Selomulya, Magdalena Plebanski.
(European Respiratory Society Congress Poster Presentation, 2018)
Quantitative Imaging and Deep Profiling of Collagen Structure in Triple Negative Breast Cancer
Joe Yeong, Laurent Cole, Jeffery Chun Tatt Lim, Aye Aye Thike, Jabed Iqbal, Bernett Lee, Weimiao Yu, Puay Hoon Tan. (US Chinese American Pathologist (USCAP) Association Annual Meeting Poster presentation, 2018)
2017
Feng Liu, MD, Jing-Min Zhao, MD, Hui-Ying Rao, MD, Wei-Miao Yu, MD, Wei Zhang, MD, Neil D. Theise, MD, Aileen Wee, MBBS, FRCPath, FRCPA, and Lai Wei, MD. Am J Clin Pathol. 2017 Nov 20;148(6):502-512. doi: 10.1093/ajcp/aqx104
Novel Therapeutic Targets and Emerging Treatments for Fibrosis
Samuel CS, Hewitson TD. Editorial: Novel Therapeutic Targets and Emerging Treatments for Fibrosis. Front Pharmacol. 2017 Nov 14;8:824. doi: 10.3389/fphar.2017.00824. PMID: 29184502; PMCID: PMC5694437.
New Standards in Fibrosis Quantification: The Value of Label-free Second Harmonic Generation
Li Chen, Mathieu Petitjean. November 13-14, 2017, Boston USA.
(Anti-fibrotic Drug Development Forum, 2017)
Detailed analysis of the antifibrotic effect of INT-767, a dual FXR/TGR5 agonist in an obese mouse model of diet-induced and biopsy-confirmed NASH
Sanne Skovgård Veidal, Michael Feigh, Henrik B Hansen, Jacob Jelsing, Niels Vrang, Mathieu Petitjean, Li Chen, Mark Young, Jonathan Roth. Presidential Award Poster. October 20-23, 2017. (AASLD Poster Presentation, 2017)
Application of Human NASH-based Transcriptome and Metabolome Profiles in Preclinical Models
Martine Morrison, TNO, Metabolic Health Research, The Netherlands.
(AASLD Poster Presentation, 2017)
Feng Liu*, Jing-Min Zhao, Pei-Hao Liu, Hui-Ying Rao, Wei Zhang, Nan Wu, Lai Wei.
(EASL Poster Presentation, 2017)
Jason Chang, George Boon-Bee Goh, Wei Qiang Leow , Yayun Ren , Wei Keat Wan , Kiat Hon Lim , Chee Kiat Tan. (EASL Poster Presentation, 2017)
M. Petitjean, J. Schwartz, Li Chen. March 26-30 2017.
(Keystone Symposia on Injury, Inflammation and Fibrosis Poster Presentation, 2017)
Quantification of Septa in Liver Fibrosis Using Second Harmonic Generation Imaging
Li Chen, Mohammad Naser, et al. March 26-30 2017.
(Keystone Symposia on Injury, Inflammation and Fibrosis Poster Presentation, 2017)
Comparative Efficacy of INT-767 Vs. Liraglutide in Gubra AMLN Mice
Jonathan Roth et All. Intercept Pharmaceuticals. Keystone Symposia Workshop: approaches to NASH Treatment, March 7th 2017.
Yameng Sun et all. Journal of Hepatology, doi: 10.1002/hep.29009.
Systematic Quantitation of Histologic Patterns Shows Accuracy in Reflecting Cirrhotic Remodeling
Yan Wang, Wei Huang, Ruhua Li, Zhaoqiang Yun, Youfu Zhu, Jinlian Yang, Hailin Liu, Zhipeng Liu, Qianjin Feng, Jinlin Hou. J Gastroenterol Hepatol. 2017 Sep;32(9):1631-1639. doi: 10.1111/jgh.13722.
Quantitative Imaging and Deep Profiling of Collagen Structure for Asian Triple Negative Breast Cancer
Dr Yu Weimiao, Guangzhou, China. (3rd Digital Pathology Congress Asia-Pacific, 2017)
Multiphoton Imaging of Breast Cancer
Clinnovate Health UK, University of Glasgow.
(Glasgow Molecular Pathology Node Symposium, 2017)
Novel Methods in Imaging and Quantification of Skeletal Muscle Fibrosis Associated with Severe Muscular Dystrophy
David W. Hammers, Coar C. Coker, Li Chen, Matt Petitjean, Elizabeth R. Barton, H.Lee Sweeney. March 26-30 2017. (Keystone Symposia on Injury, Inflammation and Fibrosis Poster Presentation, 2017)
Use of Second Harmonic Generation (SHG) and 2-Photon Emission Imaging to Quantify and Describe the Structure of Tissue Fibrosis in the Rat TNBS Intestinal Fibrosis Model
Laura Johnson, Li.Chen, P. Higgings et al. March 26-30 2017.
(Keystone Symposia on Injury, Inflammation and Fibrosis Poster Presentation, 2017)
Evaluation of Liver Fibrosis: “Something Old, Something New…“
Almpanis Z, Demonakou M, Tiniakos D. Evaluation of liver fibrosis: “Something old, something new…”. Ann Gastroenterol. 2016 Oct-Dec;29(4):445-453. doi: 10.20524/aog.2016.0046. Epub 2016 May 27. PMID: 27708509; PMCID: PMC5049550.
2016
Yamamoto S, Oshima Y, Saitou T, Watanabe T, Miyake T, Yoshida O, Tokumoto Y, Abe M, Matsuura B, Hiasa Y, Imamura T. Quantitative imaging of fibrotic and morphological changes in liver of non-alcoholic steatohepatitis (NASH) model mice by second harmonic generation (SHG) and auto-fluorescence (AF) imaging using two-photon excitation microscopy (TPEM). Biochem Biophys Rep. 2016 Sep 25;8:277-283. doi: 10.1016/j.bbrep.2016.09.010. PMID: 28955967; PMCID: PMC5614464. https://doi.org/10.1016/j.bbrep.2016.09.010.
Feng Liu et al. Laboratory Investigation (2016) , 1-9. 2016 USCAP.
Second Harmonic Generation Microscopy: A Novel Automated Method for Quantification of Hepatic Steatosis in Chronic Liver Disease
George B. Goh, Wei Qiang Leow, Shen Liang, Wei Keat Wan, Dean C. Tai, Kiat Hon Lim, Chee Kiat Tan, Jason P. Chang. (AASLD Poster Presentation, 2016)
Development and Validation of an Automated Optical Imaging System to Differentiate Severity of Hepatitis B- and Non-alcoholic Steatohepatitis-related Fibrosis in Patients with Concomitant Disease
Jason P. Chang, George B. Goh, Wei Qiang Leow, Wei Keat Wan, Dean C. Tai, Kiat Hon Lim, Chee Kiat Tan. (AASLD Poster Presentation, 2016)
L. Blaise, M. Albuquerque, C. Neuzillet, N. Guedj, J. Cros, V. Paradis, INSERM UMR1149 Beaujon Hospital, Clichy, France. (AASLD Poster Presentation, 2016)
Objective Quantitative Evaluation of Anti-fibrotic Agents in Animal Models
Kenneth Zhang, Li Chen, Bertha Xue, Chen Hu, Laurent Gole, and Chuan-Chu Chou. September 21-25, 2016. (The First International Conference on Tissue Repair, Regeneration, and Fibrosis Poster Presentation, 2016)
Christopher J. Mulder, Zachary Goodman, Caroline Bolduc, Matthew F. Raines, Katherine M. Cebe, Lakshmi Alaparthi, Fanny Monge, Peter G. Traber, Dean Tai, Stephen A. Harrison.
(APASL, 2016)
2015
Wang, TH., Chen, TC., Teng, X. et al. Automated biphasic morphological assessment of hepatitis B-related liver fibrosis using second harmonic generation microscopy. Sci Rep 5, 12962 (2015). https://doi.org/10.1038/srep12962
Low Cost and Compact Nonlinear (SHG/TPE) Laser Scanning Endoscope for Bio-medical Application
Jia Yun Liu, Ken Choong Lim, Hao Li, Hon Luen Seck, Xia Yu, Shaw Wei Kok, and Ying Zhang “Low cost and compact nonlinear (SHG/TPE) laser scanning endoscope for bio-medical application”, Proc. SPIE 9304, Endoscopic Microscopy X; and Optical Techniques in Pulmonary Medicine II, 93041K (2 March 2015); https://doi.org/10.1117/12.2078809
David Sevrain, Matthieu Dubreuil, Grace Elizabeth Dolman, Abed Zaitoun, William Irving, Indra Neil Guha, Christophe Odin, and Yann Le Grand. Biomed. Opt. Express, 1209-1218 (2015).
Digital Whole Slide Imaging and Two Photon Microscopy for Liver Fibrosis Scoring and Quantification
Jolanta Jedrzkiewicz, Mary P Bronner, Erinn Downs-Kelly, Jessica Kohan, Leslie Rowe, Dean Tai, Mohamed Salama. Modern Pathol. 2015; 28(2):167A.
Current Strategies for Quantitating Fibrosis in Liver Biopsy
Wang, Yan & Hou, Jin-Lin. (2015). Chinese medical journal. 128. 252-8. 10.4103/0366-6999.149223.
Manu Jain, MD; Brian D. Robinson, MD; Maria M. Shevchuk, MD; Amit Aggarwal, PhD; Bekheit Salamoon, MBBS; Justin M. Dubin, BS; Douglas S. Scherr, MD; Sushmita Mukherjee, PhD, Ms. Arch Pathol Lab Med. 2015; 139:796-804.
Rowe L, Etman A, Kohan J, Prchal J, Ho G, Liu DQ, Salama M. Modern Pathol. 2015; 28(2):523A.
2014
Tilbury K, Lien CH, Chen SJ, Campagnola PJ. Biophysical journal. 2014;106(2):354-65.
2011
Abraham T, Hirota JA, Wadsworth S, Knight DA. Pulmonary Pharmacology & Therapeutics. 2011;24(5):407-96.
Aligned Collagen is a Prognostic Signature for Survival in Human Breast Carcinoma
Conklin MW, Eickhoff JC, Riching KM, et al. The American Journal of Pathology. 2011;178(3):1221-32.
2009
Tai DC, Tan N, Xu S, et al. Journal of Biomedical Optics. 2009; 14(4):044013.
2008
Sun W, Chang S, Tai DC, et al. Journal of Biomedical Optics. 2008;13(6):064010.
Second Harmonic Microscopy to Quantify Renal Interstitial Fibrosis and Arterial Remodeling
Strupler, M., Hernest, M., Fligny, C., Martin, J. L., Tharaux, P. L., and Schanne-Klein, M. C. (2008), Journal of Biomedical Optics 13, 054041