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Keystone Symposia: Injury, Inflammation and Fibrosis 2017

The Keystone Symposia will bring together basic biologists and translational and clinical researchers to discuss core mechanisms underlying inflammation and fibrosis, to compare and contrast fibrotic diseases, preclinical models, the potential for regeneration and regression of fibrosis, and potential therapies.

The interaction between the host genetics, the environment and the microbiome in the pathogenesis of fibrotic diseases will be addressed.

Also, non-invasive methods to assess fibrosis including advanced imaging and intermediate biomarkers will be discussed. This conference will be a unique opportunity for investigators who are focused on organ-specific diseases – i.e., medical subspecialists – to participate in cross-disciplinary, multi-organ discussions in order to gain new insights into their research. 

The following presentations by HistoIndex collaborators took place at this year's Keystone Symposia:

- Novel Methods in Imaging and Quantification of Skeletal Muscle Fibrosis Associated with Severe Muscular Dystrophy

David W. Hammers, Coar C. Coker, Li Chen, Matt Petitjean, Elizabeth R. Barton, H.Lee Sweeney.

- Use of Second Harmonic Generation (SHG) and 2-Photon Emission Imaging to Quantify and Describe the Structure of Tissue Fibrosis in the Rat TNBS Intestinal Fibrosis Model.

Laura Johnson, Li.Chen, P. Higgings et al.

- Concurrent Semi-Automated Quantification of Liver Fibrosis and Fat Using Label-free Second Harmonic Generation Imaging in Animal Models.

M. Petitjean, J. Schwartz, Li Chen.

- Quantification of Septa in Liver Fibrosis Using Second Harmonic Generation Imaging.

Li Chen, Mohammad Naser, et al.

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