Assessing and Quantifying Hepatic Steatosis with Second Harmonic Generation and Two-photon Excited Fluorescence

A study by the Singapore General Hospital (SGH) demonstrates that Second Harmonic Generation (SHG) and Two-photon Excitation Fluorescence (TPEF) by HistoIndex can be used to precisely quantify Hepatic Steatosis (HS) in a continuous-scale measurement, and also detect subtle interval nuances that may not be very apparent with the use of traditional approaches.

LinkedIn Quantification of Hepatic Steatosis in Chronic Liver Disease


This novel SHG/TPEF method is very relevant as a crucial tool in the current clinical trials interrogating the effectiveness of therapeutic agents for NAFLD and NASH.

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