NASH Highlights

 

24 August 2017

Demand for liver transplant for NASH set to continue rising

Given population obesity trends, the increase in the demand for liver transplantation (LT) for nonalcoholic steatohepatitis (NASH) noted since 2000 is expected to continue, according to a study published online Aug. 17 in Hepatology.

 

21 August 2017

NASH Biomarkers Market Analysis by Type, End-use and Segment Forecasts, 2014 - 2025

The global non-alcoholic steatohepatitis (NASH) biomarkers market is expected to reach USD 2.09 billion by 2025, according to a new report by Grand View Research, Inc.

 

21 August 2017

Low thyroid function predicts NASH, fibrosis in patients with fatty liver

“The prevalence of NASH and advanced fibrosis associated with [thyroid-stimulating hormone levels] was significantly higher in subjects with subclinical hypothyroidism than in those with normal thyroid function,” the researchers wrote.

 

18 August 2017

 

Organ crosstalk: Fatty liver can cause damage to other organs

According to the article, fatty liver increases the risk of chronic liver diseases (liver cirrhosis and liver cancer), as well as type 2 diabetes and cardiovascular diseases. How this happens is that the fatty liver increasingly produces glucose, unfavorable fats and proteins, such as the hepatokine fetuin-A, all of which it releases into the bloodstream and enters other organs, triggering adverse reactions.

 

15 August 2017

 

Fibrosis, not NASH, predicts death, disease in fatty liver

Nonalcoholic steatohepatitis did not increase the risk for liver-related morbidity, overall mortality or the time to development of severe liver disease in patients with nonalcoholic fatty liver disease, according to recently published data. However, fibrosis stage can be used as a significant marker.

 

26 July 2017

NASH linked to early markers of hypertrophy

Whether diastolic dysfunction similarly portends a risk of future [heart failure] among patients with NAFLD and/or NASH remains unknown, and we eagerly await well-designed, prospective studies to characterize this relationship.

 

19 July 2017

 

AASLD releases NAFLD practice guides for screening, treatment

“There is a paucity of data regarding the incidence of NAFLD in the general population. ... The incidence rates for NAFLD in the general population of Western countries are even less commonly reported [than those in Asian countries],” the researchers wrote.

In contrast to the incidence data, there is a significantly higher number of publications describing the prevalence of NAFLD in the general population.

 

6 July 2017

Millions of people are living with a silent disease they've likely never heard of

... And NASH is set to surpass hepatitis as the biggest reason for liver transplants by 2020. That is seriously alarming!

 

5 July 2017

NASH: KOL Insight

Key takeaway from experts on current study designs and endpoints, and the challenges facing novel therapies such as long-term safety, cost and diagnosis.

 

3 July 2017

Fatty liver disease can be a silent killer

According to a report in Singapore's The New Paper (TNP), Non-alcoholic fatty liver disease - which can lead to liver cirrhosis or cancer - is on the rise in Singapore.

 

30 June 2017

 

AASLD Foundation announces $3.34 Million in liver disease research and career development funding

“Liver disease continues to be a critical healthcare issue in the United States and internationally. Despite recent strides and successes in the treatment of many liver diseases, AASLD Foundation understands there is still much work to be done and more funding must be made available to those interested in hepatology.” - Bruce R. Bacon, MD, FAASLD, AASLD Foundation Chair.

26 June 2017

Looking for clues for dangerous fatty liver disease

"When you combine the fact that the natural history of the disease is unclear; it's difficulty to diagnose, treat and stage it; and there's no FDA-approved medicine, it becomes a huge issue." - Dr. Jaideep Behari, associate professor of medicine at the University of Pittsburgh and director of Fatty Liver Clinic.

Click on the headline to read the article on fatty liver disease and nonalcoholic steatohepatitis (NASH).

Story by Medical Xpress

 

19 June 2017

First-degree relatives of patients with NAFLD-cirrhosis at risk for advanced fibrosis

"According to researchers, first-degree relatives of patients with nonalcoholic fatty liver disease and cirrhosis have a 12-times higher risk for developing advanced fibrosis compared with first-degree relatives without NAFLD."

Story by Healio

 

13 June 2017

Non-Alcoholic Fatty Liver Disease (NAFLD) Forecast in 11 Major Markets 2017-2027

Report by Research and Markets.

 

6 June 2017

 
New study indicates that drinking even a few cups a day may prevent hardening of the liver, reports the Journal of Hepatology. So don't forget that cuppa, everyone!

 

 

1 June 2017

EMA consults on regulatory requirements for chronic liver disease drugs

“Specifically, EMA says the diseases pose a significant challenge for drugmakers to study, as all three have a long progression and symptoms that are either unspecific or non-predictive of long-term outcomes. Furthermore, EMA says the use of "hard" clinical outcomes like liver transplantation or death raise feasibility issues for studies, and the need for repeated liver biopsies deters patients from enrolling in studies and increases risk.

Because of these challenges, EMA says there is a strong need for a validated surrogate endpoint to reduce the need for biopsies.”

Story by Regulatory Affairs Professional Society

 

31 May 2017

Commissioner Carlos Moedas on the importance of research and innovation in fighting NAFLD and NASH

During the first European- NAFLD-NASH Policy Summit last month, Carlos Moedas, European Commissioner for Research, Science and Innovation, stressed the "need to scale up efforts in research and innovation [to] develop simple, cost-effective and non-invasive tests" that will allow to "improve guidance to member states on primary care and better management".

Read more and watch this video to hear the full message.

Story by the European Liver Patients Association (ELPA)

Note: Organised by the ELPA, the first European- NAFLD-NASH Policy Summit took place on May 31 this year. The event addressed potential measures to reduce the burden of NAFLD/NASH.